this post was submitted on 11 Jun 2025

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Varyk@sh.itjust.works

YSK that psilocybin, the active ingredient in magic mushrooms, is 50% less toxic than caffeine. (sh.itjust.works)

submitted 1 month ago* (last edited 1 month ago) by Varyk@sh.itjust.works to c/youshouldknowfacts@sh.itjust.works

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caffeine only needs 190 mg per kilogram of body weight to have a 50/50 chance of killing you, whereas you would need 280 mg per kilogram of body weight of psilocybin.

caffeine

psilocybin

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[–] Sturgist@lemmy.ca 2 points 1 month ago (1 children)

Ok cool. It just seems like you're glossing over the actual cause of the bad trip. It had nothing to do with the movie.

[–] Varyk@sh.itjust.works 0 points 1 month ago* (last edited 1 month ago) (1 children)

glossing over? by directly addressing your concerns?

I wasn't with you when you took that fateful trip, so I am not absolutely certain what went wrong for you. I'm responding to the story you've provided.

Setting is very important during a psychedelic trip, and putting on a loud, emotionally aggressive movie that starts with a creepy mannequin is not a psychedelics setting I would ever recommend.

you are making very strong recommendations to other people based on your single anecdotal experience.

That's my experienced take on your information.

[+] Sturgist@lemmy.ca 1 points 1 month ago (1 children)

[removed by mod]

[–] Varyk@sh.itjust.works 1 points 1 month ago* (last edited 1 month ago) (2 children)

Your concern over dosage(~25g) is directly contradicted by evidence.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9751063/

show your sources. this community requires evidence for claims.

25 grams of mushrooms is not a very high dose for experienced users or for patients in therapeutical settings.

Setting is always crucial to a psychedelic experience, according to the FDA, NIH, and psychedelic communities.

https://erowid.org/experiences/exp.php?ID=91095

magic mushrooms should be taken responsibly, and people following the basic recommended guidelines will be fine.

you can tell your own story without exaggerating things.

baseless alarmism is specifically what this post is fighting against.

[–] Sturgist@lemmy.ca 3 points 1 month ago (1 children)

Healingmaps dose guide.

The strain available locally where I grew up was psilocybin cubensis. Golden Teachers were the more common variety, Penis Envy was occasionally available.

Note that I am talking about consuming DRY mushrooms. 25g of fresh mushrooms is about 2.5g dry. For cubensis that's a moderate but not insane dose. 25g dry is closer to 250g wet.

Psychedelic Support.

Synthetic Psilocybin Doses in Research

For research studies, a synthetic or extracted version of psilocybin is typically used. The psilocybin molecule is produced in a laboratory, meaning no mushrooms are needed. Extraction methods isolate psilocybin from mushrooms. Pure psilocybin in capsules allows researchers to administer a precise and consistent dose to all clinical trial participants. Since they are not using dried mushrooms, the dosage is given as milligrams of synthetic psilocybin. Some studies even take into account a person’s body weight and give doses as mg of psilocybin/kg of body weight or as mg of psilocybin/70kg (the average human weight), but at least one study did not find differences in how people felt when doses were adjusted for body weight [2].

Here are example doses of psilocybin (note: not dried magic mushrooms) given in research studies. Most people will notice some small perceptual shifts after taking 2-4 mg of psilocybin. Psychoactive effects are experienced after ingesting 8-20 mg, with the majority of people reporting mystical experiences at a dose of 20 mg or higher [4].

-10 mg psilocybin – low dose.
-20-30 mg psilocybin – medium or standard dose.
-30-40 mg psilocybin – high dose.
->40 mg psilocybin – very high dose. Hi

Synthetic or Extracted Psilocybin vs Mushroom Dosage

You may be wondering how extracted or synthetic psilocybin doses compare to dried mushrooms.

As a comparison for dosage [3], there is typically 1% psilocybin per 1 gram of dried Psilocybe cubensis mushrooms. For example, 3.5 grams (equivalent to an eighth ounce) of dried Psilocybe cubensis is likely to contain 35 mg of psilocybin (high dose), and 2.0 grams of dried mushrooms contain 20 mg of psilocybin (standard dose). Keep in mind that psilocybin levels in dried mushrooms can vary quite a bit between species, ranging from 0.1% to 2% of dry weight. Mushroom caps usually have higher psilocybin levels than mushroom stems.

To use your own sources.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9751063/

Your fist link says they use a set 25_mg_ dose of extracted psilocybin.

https://erowid.org/experiences/exp.php?ID=91095

The person recounting this trip consumed 2.6g of dried mushrooms and had a very intense trip. That should be about 26mg of psilocybin.

My experience on 25g of dried mushrooms was likely around 250mg of psilocybin.

Does this count as bringing sources to the table?
Or are you going to delete my comments again?

[–] Varyk@sh.itjust.works 1 points 1 month ago* (last edited 1 month ago)

"does this count as bringing sources to the table?"

yes, providing relevant sources counts as "bringing sources to the table".

"are you going to delete my comments again?"

nope, your previous comments were deleted for alarmism and lacking sources.

now you are sharing your own experience and general facts about psilocybin dosage supported with evidence.

looks good to me.