Metabolic Health

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A place to discuss metabolic health research, papers, talks, etc.

This topic can touch upon many people's personal triggers, so please be civil.

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Dr. Roshani Sanghani, MD is the founder of Reisaan Health in Mumbai, India. She is a superspecialist in hormone imbalance in patients with Type 2 and Type 1 diabetes and she is American board-certified in Endocrinology, Diabetes, and Metabolism. Discover the truth about diabetes management in this eye-opening discussion with Dr. Eric Westman and Dr. Roshni Sogani. In this video, they reveal powerful insights into reversing diabetes through lifestyle changes, nutrition, and low-carb diets, going beyond traditional medical advice. Dr. Sogani, a renowned endocrinologist, shares her journey of moving away from medication-focused treatment and helping patients take control through comprehensive lifestyle solutions. If you've ever felt frustrated by conventional diabetes treatments or wanted to know how to manage diabetes naturally, this video is a must-watch!

She is doing a book circuit for her new book "Turn around Diabetes: The Step-by-Step Guide to Navigate Type 2 (and Type 1) Diabetes with Less Medication"

What makes this really interesting is she focuses on the approach to vegan diabetes management, most vegan food has a large carb to protein ratio, so its a challenging environment in which she has outlined a path to success.

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A nice presentation of a study of 99 participants over 6 months and their diabetes control, using a low carb (20% of diet) intervention.

HbA1c down by 1% in 3 months!

20% is a low carb diet, not a ketogenic diet, its 85g of carbs, or about 340 kcal from carbs per day.

I'm really impressed at the improvements in this cohort with a mild dietary intervention, promising work!

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A interesting THEORY of action regarding lipid rafts in the cell membrane and the observed effects of both elevated blood glucose and seed oils, and possibly statins, in impacting insulin resistance (these seem like different things, but they seem to have similar outcomes). He goes over the theory at the 32 minute mark, before that he sets up background on the lipid system.

phospholipid bilayer is not a homogenous ocean of phospholipids, but is composed of islands of phospholipids (rafts) that float in the cell membrane, the lipid raft composed of large amounts of cholesterol and insulin receptors.

Depletion of lipid raft cholesterol detrimental to lipid raft function and impairing insulin receptor activation - leading to insulin resistance.

Anything that impacts that lipid raft/cholesterol function seems central to insulin resistance, and would link excess sugar intake and oil intake with insulin resistance as they both have demonstrated impact on these rafts.

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Low Carb Down Under - Grant Schofiled PhD

Video description - Grant's background

Prof. Grant Schofield is the Professor of Public Health at Auckland University of Technology, director of the University’s Human Potential Centre, former Chief Scientific Adviser to the Ministry of Education in New Zealand, co-author of four best-selling books and Chief Science Officer for PREKURE.

Grant’s career has focused on preventing the diseases of modern times, and seeing what it takes to help people live a long, healthy and happy life. He lives and breathes the motto “be the best you can be”, and sees this as a game-changer for the health system – capable of transforming the current health (sickness) model, to one in which we aspire to be well. He is redefining public health as the science of human potential; the study of what it takes to have a great life.

Prof. Schofield is well known for thinking outside the box and challenging conventional wisdom in nutrition and weight loss, as well as physical activity and exercise.