this post was submitted on 17 Nov 2023
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Groundbreaking Discovery: Inhibiting Key Enzyme May Halt Parkinson’s Disease Progression (scitechdaily.com)
submitted 1 year ago by Bebo@literature.cafe to c/science@lemmy.world
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This study reveals that inhibiting a specific enzyme, USP30, in a mouse model can protect dopamine-producing neurons. This finding halts the disease’s progression and opens the door to new therapeutic possibilities for the 10 million people affected by Parkinson’s worldwide.

DOI: 10.1038/s41467-023-42876-1

https://www.nature.com/articles/s41467-023-42876-1

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[–] SocialMediaRefugee@lemmy.world 2 points 1 year ago

Related article: https://www.frontiersin.org/articles/10.3389/fphar.2022.851654/full

Best I can deduce USP30 is in the mitochondrial wall and its function is to regulate mitochondrial apoptosis.

"At the cellular level, several studies provide evidence for the pivotal role of USP30 involved in mitochondrial cell death and apoptosis. Mitochondria are fundamental in the orchestration of cell death pathways as they play a central role in energy production and metabolism."