We found that sedentary behavior was independently associated with higher all-cause and CVD mortality.

In contrast, all-cause mortality was reduced in the highest quintile of coffee intake, and the decreased risk for CVD mortality was significantly associated with any amount of coffee consumption.

Notably, the results of a joint analysis of this study identified that that the association of sedentary with increased mortality was only observed among adults with no coffee consumption but not among those who had coffee intake. Given that coffee is a complex compound, further research is needed to explore this miracle compound.