SSRIs
- If you have a higher dosage but you are able to use a lower one, depending on the medication, you might be able to cut the pill or dose in half.
- Mexican pharmacies may have SSRIs over the counter.
Tapering if necessary
- Check your SSRI’s half-life to see how long you have; sudden discontinuation can trigger severe withdrawal (brain zaps, dizziness, panic attacks, depression).
- If you must stop without access, taper slowly over weeks by reducing doses in 5mg increments (liquid compounding pharmacies can help).
- In case of sudden withdrawal, these might help:
- Increase 5-HTP or Tryptophan Intake
- 5-HTP: 100 mg 2x daily.
- Natural sources: Turkey, eggs, cheese, oats, seeds (pumpkin/sunflower), and dark chocolate.
- Increase 5-HTP or Tryptophan Intake
- Use NAC (N-Acetyl Cysteine) to Reduce Withdrawal Effects
- Helps restore glutamate balance disrupted by antidepressant withdrawal.
- Dose: 600-1200 mg/day.
- Exercise (Even Light Walking) to Boost Serotonin Naturally
- 20+ minutes a day helps regulate mood and reduce withdrawal symptoms.
- Light Therapy (If Seasonal Affective Symptoms Are a Factor)
- Light therapy - use a 10,000 lux light box for 30 min in the morning.
- How to Safely Taper Off Drugs video: https://www.youtube.com/watch?v=VY820dpjdq8
Prescription Alternatives
Note: these are not substitutes for prescription medication, but they might help.
- 5-HTP (Precursor to Serotonin) – Helps replenish serotonin levels, similar to an SSRI.
- Dose: 50-200 mg/day (start low).
- St. John’s Wort (Natural SSRI Alternative) – Shown in studies to be as effective as some antidepressants, but interacts with many medications.
- Dose: 300 mg 2-3x daily.
- Saffron Extract (Natural Serotonin Booster)
- Studies show it’s as effective as Prozac for mild to moderate depression.
- Dose: 30 mg/day (crocin + safranal active components).
- Best Source: Buy standardized saffron extract (not just cooking saffron).
- Rhodiola Rosea (Adaptogen for Mood & Energy)
- Improves serotonin & dopamine levels, reduces fatigue & stress.
- Dose: 200-500 mg/day.
- Best for: Depression with low energy & fatigue.
- L-Theanine (Calming, Balances Neurotransmitters)
- Found in green tea, increases dopamine & GABA, reduces anxiety.
- Dose: 200-400 mg/day (safe long-term).
- Lion’s Mane Mushroom (Supports Nerve Regeneration & Mood)
- Stimulates brain-derived neurotrophic factor (BDNF), similar to SSRIs.
- Dose: 500-1500 mg/day.
- Magnesium Glycinate or L-Threonate (Natural Anti-Depressant)
- Critical for serotonin production, reduces anxiety & depression.
- Dose: 400-600 mg/day.
- Omega-3 Fatty Acids (Brain Health & Mood)
- Found in fish oil; supports dopamine & serotonin receptors.
- Dose: 2000 mg/day (high EPA content preferred, ~1000 mg EPA minimum).