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Puyo Puyo Champions has a one-handed controller preset. D-pad or ABXY to move, shoulder buttons to rotate.
Only caveat is that if you want to play online, only the Switch version is actively populated, so I can't recommend the game on any other platform.
Curious Expedition!
Pinball with arrow keys mapped to left and right flippers?
I went through the same thing a while back
I played a lot of turn based RPGs
Caves of Qud is keyboard only option (no mouse), mostly just need wasd. Definitely an atypical RPG but very fun all the same.
I've been playing Jotunnslayer: Hordes of Hel recently on PC and despite being relatively action heavy it's 99% left hand (WASD + Q + space)
deep rock survivor is a surprisingly fun and simple game that is designed for one handed play
Not really helpful in terms of gifts as they are free to play mmo's and they use keyboard and mice but both have some script capabilities which allow for one to be able to play alternating between keyboard and mouse or not use mouse at all. Its the cryptic games champions online and star trek online. One thing you could do is play them yourself and learn the scripting and then gifting them useful scripts. with champions online turning the block to a toggle is the big script thing and with star trek online its making an emergency power to spacebar one (this is reference to a script where tapping space works through all the abilites put into a shorcut area that can be swapped out). really basic ones will dump everything into spacebar but more nuanced ones will have a key for low cooldown abilities and one for long cooldown offense and long cooldown defense. there really is no limit to the messing around.
Dungeon crawl stone soup. Can be played with keyboard only.
All the games. Every last one of them.
One handed controllers exist.
thronefall is a fun little TD/RTS style game with a nice visual style and good rouglite-esque progression.
If it's more permanent show them an Azeron Cyro at https://www.azeron.eu/ It's a mouse with a thumbstick, you can play almost any PC game with one hand. Comes in both right and left handed versions.
One Finger Death Punch and One Finger Death Punch 2
What more is there to say? The reason why that works perfectly is already in the title of the game.
Caution: this game is addictive
Atomic Heart
Rafa Nadal is right handed and plays left handed. If someone has issues with a non-dominant hand then it's time to start making the other one dominant.