I was on Graphene but switched to Calyx. Personally, I find easier. The integration of microG helps with a few things, such as apps stuck using Google's push notification service and apps that require SafetyNet. I was going to try Graphene again, but I was thinking of waiting for a new phone.
Calyx is very nice. I've found it to be no fuss at all.
It's 'adapt or die' at the moment for 3rd party Reddit apps. I was kind of hoping that the developer would pivot to Lemmy or add Lemmy functionality to the app. Infinity was my go-to app before the apocalypse.