Biology

Frogs, salamanders, and other amphibians around the world face mounting threats from a devastating fungus, climate change, habitat loss -- and road mortality. Among these, roads pose a uniquely immediate danger by cutting through critical migration corridors, allowing vehicles to crush millions of animals each year.

Now, a new, first-of-its-kind study offers powerful evidence that a simple intervention -- wildlife underpass tunnels -- can dramatically reduce these amphibian deaths and help preserve ecosystems.

In research spanning more than a decade, scientists and citizens from the University of Vermont, the Vermont Agency of Natural Resources, and the local community assessed the effectiveness of two wildlife underpasses installed under a road in Monkton, Vermont. The results were striking: an 80.2% reduction in amphibian deaths.

cross-posted from: https://lemmygrad.ml/post/7976516

Thoughts on this?

The video is about an hour long.

Honestly, really raises questions about a philosophy of life and how to systematize it.

This is a presentation by the Bath Royal Literary and Scientific Institution.

You can listen to it while you're doing other things but the slides are interesting to me.

Scientists have attempted to map the human cell since the first microscope was invented more than 400 years ago. But many components of the cell still remain uncharted.

“ We know each of the proteins that exist in our cells, but how they fit together to then carry out the function of a cell still remains largely unknown across cell types,” said Leah Schaffer, Ph.D., a postdoctoral research scholar at UC San Diego School of Medicine.

Now, Schaffer and her colleagues at UC San Diego — in collaboration with researchers at Stanford University, Harvard Medical School and the University of British Columbia — have created a comprehensive, interactive map of U2OS cells, which are associated with pediatric bone tumors. They combined high-resolution microscope imaging and biophysical interactions of proteins to map the subcellular architecture and protein assemblies in the cell. The map revealed previously unknown protein functions and will help the researchers understand how mutated proteins contribute to diseases such as childhood cancers. It will also serve as a reference for developing maps of other cell types. The study will be published on April 9, 2025 in Nature.

“Based on cell biology 101 and textbook pictures of cells, you might think that we understand everything about a cell. But what’s remarkable is that for no human cell type do we really have a proper parts catalog and assembly manual,” said co-senior author Trey Ideker, Ph.D., a professor of genetics in the Department of Medicine, an adjunct professor in the Departments of Bioengineering and Computer Science and Engineering, and a member of Moores Cancer Center at UC San Diego.

The mapping projects referenced in this story are really fucking cool:

https://www.proteinatlas.org/

https://musicmaps.ai/u2os-cellmap/

The world has been gripped by the case of Australian woman Erin Patterson, who was charged with the murder of three people after allegedly serving them a lunch of beef wellington containing poisonous death cap mushrooms (Amanita phalloides).

A new element of the sensational story emerged in court this week, when prosecutors reportedly alleged Patterson used iNaturalist to locate and visit places where death cap mushrooms were known to grow.