askchapo

A person I know and care for has severe lifelong depression. They did supervised ketamine infusions (~1 mg/kg body weight subcutaneous infusions). Initially weekly then less frequent I think fortnightly, then they ran out of money. It helped them significantly while they could afford it.

I DIY the same protocol with pharmaceutically pure sterile solutions I prepare. Ketamine possibly has some bacteriacidal properties and subcutaneous injection is less risky but I would urge anyone without training to not do this without first consulting someone with the training or sourcing prepared IV solutions. Never IV ketamine as you stand a significant risk of losing cordination with a needle in you.

I initially found monthly quelled nerve pain and helped with depression massively. Like turn-my-life-round with establishing stable routines massively. Now I get by with 3 monthly. I would probably not use it if I found I had to continue using it frequently due to the potential for side effects.

I have not seen good evidence that daily low-dose protocols work well. Reviews seem to support ~0.5 - 1.5 mg/kg doses at varying frequencies. Nasal dosing requires concentrations that are hard to achieve in a racemic preparation, hence patented esketamine.