this post was submitted on 30 Dec 2024
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Anyone here done ketamine therapy? (hexbear.net)
submitted 3 months ago by corgiwithalaptop@hexbear.net to c/askchapo@hexbear.net
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I qualified for financial help with one of those places that advertise on social media (Joyous, if you know it), and I've got enough to buy myself the first month of pills.

Curious as to if anyone has had experience with it. On paper it sounds like it would be great for me, but my ma is scared of it cause apparently there are horror stories going around in the news. Way I figure it, if it doesn't help, at least I get drugs.

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[–] Sulvor@hexbear.net 2 points 3 months ago (1 children)

Yeah they do quote a fair amount of studies in there but it’s late for me to scan several studies. I posted this earlier but this is probably the highest quality trial that is working towards approval for oral ketamine for depression

https://www.nature.com/articles/s41591-024-03063-x

In this phase 2 multicenter clinical trial, male and female adult patients with TRD and Montgomery–Asberg Depression Rating Scale (MADRS) scores ≥20 received open-label R-107 tablets 120 mg per day for 5 days and were assessed on day 8 (enrichment phase). On day 8, responders (MADRS scores ≤12 and reduction ≥50%) were randomized on a 1:1:1:1:1 basis to receive double-blind R-107 doses of 30, 60, 120 or 180 mg, or placebo, twice weekly for a further 12 weeks.

Not even close to daily dosing, as has been shown previously with esketamine (monthly) to be far more effective.

[–] JustSo@hexbear.net 1 points 3 months ago

Yup. I think the concern displayed by all in this thread is valid and appropriate given what's been properly studied.

Appreciate the summary/abstract. I'm getting into the NYE spirit right now and have been posting on and off all day so my capacity to read studies and grok them is diminished.