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Current uranium reserves are expected to be depleted by the end of the century, at current use.

More like somewhere between 200 years and a couple million years, assuming we fire back up and finish developing some 60-year old technologies.

Fission as a serious replacement for just coal plants is a pipe dream without asteroid mining.

pipe dream without asteroid mining

…Yeah, no. At least, not yet. Plus, the energetic and engineering challenges to just throw "asteroid mining" into the conversation are insane— So you're burning either fossil or synthetic/biofuels for the launch, electric ion (which is itself insanely difficult and expensive) I presume (so, I.e. nuclear or solar) for in-orbit maneuvering, for rocks that aren't even that that big and which you don't even have the technology to do anything with.

We have most minerals in sufficient quantities in the Earth's crust. And more importantly, we have the industrial processes to extract them efficiently. Fission is viable, has been for a long time, and will remain so for the foreseeable future.

contrary to what people pretend we still don’t have a good answer for the waste.

It's rocks. Processed "nuclear waste" is literally just rocks. (Well, technically it's solid glass covered in welded steel.) It's not like air pollution that we end up breathing in, and it's not like the chemical waste from other industries (including from batteries and rare earth extraction) which finds its way to the water cycle where it then bioaccumulates. If you're picturing a glowing green river, or a barrel full of leaking sludge— Well, that's not it.

It can't hurt you unless you powder it and huff it or build furniture with it or do something insanely stupid like that. And there are other much easier and more dangerous ways for malicious actors to hurt you too, that don't involve breaking into secure facilities to steal the some of the heaviest elements known to exist.

Dig a big hole and toss the waste a kilometer or two down the Canadian Shield, and it will sit there inert for a billion years long after it's burnt through all its dangerous levels of residual radioactivity.

We need a global fusion research project

We already have a couple of those. If everything goes perfectly for them, they might become commercially widespread right around the same time the hard-to-reverse effects of climate change might become truly apocalyptic in the second half of this century. If the past history of this field of research is any indication, they quite possibly won't really work, will work but only a decade or two behind schedule and several times over budget, or will lead nowhere except for some media coverage that's good for military-industrial stock prices or whatever.

This isn't Sid Meier's Civilization, where you can click "Global Fusion Research Project" and get a +100% boost to production after 20 turns. To quote Randall Munroe, "Magnetohydrodynamics combines the intuitive nature of Maxwell's equations with the easy solvability of the Navier-Stokes equations". Fusion is hard, or else we'd already be doing it, and though we know it's definitely possible, there's no guarantee of anything when it comes to actually engineering it.

orbital solar.

Uhh… No. Spending hundreds of millions of dollars to blast photovoltaics into an incredibly hostile environment, where they can't even be cooled by dissipating into the atmosphere, is not probably going to bring energy costs down, at current or near-future technology levels.

Plus any system capable of precisely beaming terawatts of power from space into localized collectors on the planetary surface is (1) probably by definition an omnipresent death ray and (2) probably at least going to fuck up a lot of migrating birds and components of the atmosphere.

Simple as that.

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