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I have a buddy who is a virologist. He sends me shit all the time about bird flu. The gain of function tests on it is wild. Also, note that we have seen this shit coming since 2012
Published in: Science
Summary: Demonstrated that a small number of mutations could allow H5N1 to spread via respiratory droplets in ferrets.
Link: https://www.science.org/doi/10.1126/science.1213362
Published in: Science (companion to Fouchier’s work)
Link: https://pubmed.ncbi.nlm.nih.gov/22723413/
Published in: Nature
Summary: Kawaoka’s lab showed that reassortment of H5N1 with pandemic H1N1 genes could enable airborne spread in ferrets.
Link: https://www.nature.com/articles/nature10831
Published in: Science
Summary: Chinese researchers found that hybrid viruses combining H5N1 with H1N1 pandemic genes could spread between mammals.
Link: https://www.science.org/doi/10.1126/science.1243362
Summary: Initially recommended redacting details of GoF studies due to bioterrorism concerns, later reversed.
Link: https://osp.od.nih.gov/biotechnology/nsabb-reports/
What is the point of gain of function research? Sounds unwise to devote resources to making deadly diseases deadlier.
We don't "improve" diseases to make them deadilier and then just release them. The point of gain of function research essentially boils down to "How quickly can this disease become a serious issue and what do we expect that to look like?" with covid, thanks to gain of function research we knew it would quickly mutate and decrease in severity and we could significantly reduce harm by slowing the spread until it got to the point it's at today.
Makes sense! Thank you for taking the time to summarize