this post was submitted on 30 Jun 2025
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Allow me to echo a common bit of advice. Any weight loss you do must be accompanied by an overall diet and lifestyle change in order to be permanent. Weight loss treatments and drugs are fine if you are using them with medical supervision (sounds like you are) as a way to kick start this transition in diet and lifestyle for a more healthy and manageable future for maintaining your weight and governing your health. But that lifestyle and diet change is key. Don't squander your chance to get on the right tract to start taking control of your health. Make the changes. Stick to them and you'll see success.
You should know that some evidence suggests weight loss via GLP1 drugs might be stable e.g. https://www.nature.com/articles/s41591-024-02996-7 while some contradicts this. The overall picture of long term weight loss is extremely bleak: https://pmc.ncbi.nlm.nih.gov/articles/PMC5764193/
Lifestyle changes aren't really a more sustainable intervention than anything else. For a lot of people it seems like losing weight = feel hungry for the rest of your life and commit to calorie counting forever.
Feeling hungry all the time has a lot to do with diet, I've found. You can feel more satiated with better diet choices like eating healthy fats and proteins which give a full feeling for longer than carbohydrates.
Diet and lifestyle changes are the ONLY sustainable way to keep the weight you lost off. Saying these aren't more "sustainable" than other "interventions" is wrong. Like, dead wrong. You are throwing out buzzwords here to qualify your wrong assertion in way to make it sound more right but it's still wrong. GLP-1 is an intervention. Diet and lifestyle changes are not. They are what you are doing long term. It's a different step or element to the weight loss and healthy living journey.
I'm not against GLP-1. I think it's it's great to get yourself on the path. Kick start it. I'm saying that once you stop taking it you'd better have changed some things about your relationship to exercise and food. If you go back to the way things were before, you'll gain it back. It's how you got it in the first place.
I mean the research is right there. You shouldn't confuse causality. Eating twice as much food as you need is a behaviour that starts happening for some reason, just trying really hard not to is unlikely to be successful if the underlying reason is still present. If you treat the underlying reason, which might for example be disregulation in hormone pathways involved in hunger signalling, the behaviour will likely stop on its own.
also:
intervention (IN-ter-VEN-shun) In medicine, a treatment, procedure, or other action taken to prevent or treat disease, or improve health in other ways.
The research all points to lifestyle and diet changes being the best way to keep weight off which is the core of what I was saying. The decades of evidence is thorough and conclusive. Sometimes the science does back up conventional knowledge. This is one of those times.
If you want to talk about treating the underlying reasons for physical health issues related to diet then you may as well advocate for a full psychological evaluation before any other intervention. I'm not even against that as for many people their unhealthy relationship with food and their own health is seated in trauma. Maybe even for most people but I don't care enough to search the data on that.