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It would depend on the setting, I'd think.
In an SF setting, then maybe: it could be the chemical qualities of blood that they need.
In a fantasy setting, then probably not: what they need is life taken from another. Blood is simply the material component of that life force.
The movie Lifeforce enters the chat.
Granted it's barely SF, the vampires are barely (see what I did there?) vampires, and it's objectively not a very good movie. But vampires from space sucked the life from people, and it totally rocked.