The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
It would be a nice addition to have the ability to create instance-only communities specifically for these types of topics. That could probably be done with an automod that just deletes/messages anyone who tries to post on that community.