Driving in Japan with the wheel on the right side. The first time I did that last year I drove on the wrong side of the road about 5 times and got a shock every time when I saw all the ghost drivers just to quickly realize that it's me who is driving the wrong way. This year it only happened one time, so my brain seems to adapt to that better and better.
I haven't tried it myself but id believe that for me the greatest challenge would be the gear shift with the left hand!
That is solved by the fact that all rentals seem to be automatic.
Even in countries that have been historically dominated by manual transmissions, they're starting to disappear. Where efficiency was once their main selling point, most modern automatic transmissions can do it better. Sure takes the fun out of it though.
thankfully the pedal arrangement is the same.