this post was submitted on 20 Jun 2025
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The largest ever biological study of ME/CFS has identified consistent blood differences associated with chronic inflammation, insulin resistance, and liver disease.

Significantly, the results were mostly unaffected by patients' activity levels, as low activity levels can sometimes hide the biological signs of illness, experts say.

The volume and consistency of the blood differences support the long-term goal of developing a blood test to help diagnose ME/CFS, researchers say.

The volume and consistency of the blood differences support the long-term goal of developing a blood test to help diagnose ME/CFS, researchers say.

ME/CFS' key feature, called post-exertional malaise, is a delayed dramatic worsening of symptoms following minor physical effort.

Other symptoms include pain, brain fog and extreme energy limitation that does not improve with rest.

Full paper:

Replicated blood-based biomarkers for myalgic encephalomyelitis not explicable by inactivity

https://www.embopress.org/doi/full/10.1038/s44321-025-00258-8

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