I don't have this with bright light; that makes me uncomfortable, and I sometimes want to wince at it. But I may still experience what you're describing from other stimuli. For example, crowds don't always make me uncomfortable, but the excess sensory input from cross-talking can make it hard to focus or think, and have the effect of making me unable to take things seriously.
On the other hand, certain kinds of music can have a hypnotizing effect, and make me absolutely focused on whatever task I'm in the middle of. Though I consider that more beneficial, as it helps me get through schoolwork and some "adulting". It doesn't make me completely shut down or anything like that.
Isn't Proxmox intended for servers whose only use is to run VMs? Why not go for a traditional desktop distro like Mint and run KVM, QEMU, or VirtualBox on it?
Anyway, I have heard something like this, but it probably depends on the anti-cheat. Some might run in kernel mode to deliberately detect VMs. Others won't care if you use a VM.