IIRC from reading an few earlier articles, the limiting factor is that Iran's nuclear weapons facilities are underground and can potentially only be penetrated with very large weapons. According to what I read, Israel apparently doesn't have conventional weapons that can penetrate, which would mean that the US, with heavier bombers, would have to do the strike (and Biden said that he didn't support hitting the nuclear facilities).
That being said, I haven't seen anything about using multiple weapons to impact the same spot, and I'm suspicious that with the accuracy of weapons today, it may be possible to just repeatedly hit a single spot and break through.
EDIT:
https://www.businessinsider.com/israel-not-able-to-take-down-iran-nuclear-sites-own-2024-10
https://archive.ph/nk1KB#selection-2009.126-2017.96
"Israel can damage Iran's nuclear program without US assistance, but it is unclear if it can by itself carry out the type of sustained and penetrating conventional attack that would seriously set back the program," Farzan Sabet, senior research associate at the Geneva Graduate Institute, told Business Insider.
And I guess that it's not impossible that Israel could have -- knowing that Iran has underground facilities -- built something that they've kept quiet specifically aimed at penetration.
I don't know how hard building a tandem-charge weapon is, but Israel has produced the tandem-charge Spike, and I imagine that they could have some kind of heavier tandem-charge weapon that they've quietly tucked away for this sort of situation.
It looks like Hamas has 40k members, so I guess maybe at least two non-Hamas dead for each Hamas dead.