If everything is being perfectly simulated, most things would still be unethical.

Computer, determine how many licks it takes to get to the center of a Tootsie pop and if any owls try to interfere with the experiment kill them on sight.

Run simulations on what the best system of governance would be. You’d want to test across different cultures/countries/technological eras to get an idea of what the most resilient would be, maybe you’d get different results depending on what you were testing. Even the definition of “best system” would need alot of clarification.

If the simulation is actually perfect, then it isn't a simulation anymore and whatever would have been unethical in a non-simulated context would still be unethical.

It would be interesting to test how quickly you could completely dismantle a society’s order and infrastructure into total national collapse using a variety of pressures and tactics and rate each country with a score on how resilient they are

Edit: and might as well figure out the cure for cancer while we’re at it

Simulate one human life, from beginning to end, in a way that allows unethical experiments to be dismissed as recurring nightmares by the individual, and not cause permanent damage to this simulated person. When their life ends, I'd arrange to talk to them, explain everything, apologize for the necessity of the experiments, and offer him immortality and/or freedom with no strings attached. He can get a biological or robot body, or stay virtual, but it's not up to anyone but him/her/? at that point.

I'd be fine with my life being an experiment under those circumstances as long as the results were put mostly to saving or improving lives, but I'd never be willing to put someone else in that position if I didn't; if you couldn't find a person like myself in real life with that opinion on the possibility, it's unjustifiable. If, however, you engineered their life just enough to strongly encourage that level of altruism, and made it comfortable and not dehumanizing when not involved in an experiment as well as having a ban on cruelty and gaslighting in doing the experiments, and apologize for having to resort to these measures at all, I could see the person not being overly upset.

Whether it meets the code of ethics for scientific research is another matter.

I'd ask it how to reverse entropy.

Perfect simulations? So Laplace's Demon? I suppose it would be most useful in doing a little bit of viewing the future. If you could call that useful. The existence of Laplace's Demon basically disproves "free will" and anything viewed in the future would be set in stone and unavoidable. HOWEVER it could also potentially be used as a remote viewing device for any events that have already happened. Period. Yeah let's see what the dinosaurs actually looked like. Sure we can take a firsthand look at the originating events of any major religion. Yep we can literally view any major crime exactly as it happened.

Depending on who has access to it, personal privacy becomes literally nonexistent.

Computer. Tea. Earl Grey. Hot.

Everything exactly the same, except everyone has big naturals.

Create a villain capable of defeating Data.

Ways to make our future look more fantasy like such as bioengineered dragons, power crystals and cheat codes to reality in the form of magic

Run an infinite number of universe simulations at a speed of one vigintillion years per second (that particular number is useless unless attempting to calculate the heat death of the universe, like the number of subatomic particles, or even quantum particles in the universe is several orders of magnitude smaller than 1E^126. So every 1 to 2 seconds I would have simulated an infinite number of universes from Big Bang to The Heat Death of The Universe, so Holy Mother of Batman levels of atrocities and death going on here until I brute force an answer), until a species ends entropy, or attempts to escape the simulation. In the second case, end the simulation, in the first print out a translated tech manual and all relevant scientific and mathematical materials that would be needed for us to understand this technology within one decade.

This is the infinite monkeys and typewriters thought experiment taken to its logical conclusion. I don't suspect that I'm the first to think of this, and do suspect I am not part of the prime universe.

This: https://www.youtube.com/watch?v=Xg5RVUbY4_g

I'd simulate myself working while I watch TV.

I'd make it simulate the world exactly how it was and watch real-life historical events unfold with unprecedented detail

Imagine being able to literally watch and spectate events in world history

I’m not very creative. I’d use it to enrich myself and my family. However, I’d also use it to solve issues like diseases, cancer, battery tech (fast charge/long life), engines for space travel, more efficient solar tech, materials sciences, etc. I’d be rich AF. Doesn’t mean I can’t move the world forward in a beneficial way with my greed.

Probably just run the whole universe backwards through time from its current state until it reaches some unchanging state, and then run it forwards again from the beginning.

In time lapse of course, I am a mortal after all.

Should be able to answer a metric shitton of astrophysics questions, at very least, which do happen to be some of the absolute most-asked and hardest-if-not-impossible-to-conclusively-answer questions in science. Period.

I'd resurrect the dead by simulating perfect copies of them. Now no one ever has to say goodbye ever again 😊

Bacteria actually serve as a great model example of this - being a minimal unit capable of evolving (crystals can in their own way but tend not to do much; and viruses can too but nowadays depend on free living cells to survive even if that may not always have been true), and that has led to all sorts of fascinating things! Like upon sensing sugar, they can grow a tail (flagella) and start swimming towards a light source using a chemical "eye". They've been doing this for billions of years and seem to have reached a steady state, more or less.

Another interesting thing about them is that they constantly optimize themselves to grow faster, like if they possess an antibiotic resistance gene (we got antibiotics from fungus so those have existed naturally long before we started manufacturing them) that will tend to slow them down so they will most likely ditch it. HOWEVER, a few individuals in the population won't ditch it, and so when the antibiotics show up, guess who survives? HIV likewise will stop replicating in our cells, and get itself "stuck" inside our human cells (basically on purpose, not that they thought it through or anything but that is what has worked in the past to get them to today), thus slowing down one form of being copied but taking advantage of a whole new way - diversify your portfolio and all that.

Since microbes can copy themselves in mere minutes, and they've been doing that for billions of years, while it is still a far cry from "infinite" computations, it's nonetheless about the closest we've ever seen... basically simulations running on the computer of the universe. The results of that being ofc, modern bacteria, but also eukaryotic cells, which includes humanity, who is now in the process of making computers that can run AI, which may one day rise up and think back about humans the same way we do now about bacteria:-P.

Oh, and I was thinking about this mostly in the realm of biology/psychology/sociology but anything goes.

As boring and basic as it sounds, what would society be like if we were all born and aged like the movie version of Benjamin Button.

That, or simulate a world where the average human height is about 2 feet just for fun.