If the extruder is clicking, it's able to grasp the filament. It's that it's trying to move it forward, literally can't, and it slips and makes that click. That also grinds down the filament at the wheel as well.
I've printed fine with eSun PLA+ on an Ender 3 V2, it's a very straightforward filament in my experience. Not my favourite, but it's fine. (Their cleaning filament by contrast is excellent and I recommend it highly.) I would take apart the entire filament path and make sure it is incredibly clean, because this really sounds to me like a recurring clog issue caused by some particulate matter, which can include extraheated filament hat no longer wants to melt right.