this post was submitted on 21 Dec 2023
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[–] MyPornAlt@lemmynsfw.com 83 points 8 months ago* (last edited 8 months ago) (2 children)

Meth is an approved drug for the treatment of ADHD.

It’s schedule II, while marijuana is schedule I, it’s crazy.

[–] BarrelAgedBoredom@lemm.ee 21 points 8 months ago* (last edited 8 months ago) (4 children)

Not to mention the pharmacological effects of methamphetamine are indistinguishable from Adderall when taken orally in similar doses

E: I was misremembering this study. It was measuring the physiological and behavioral effects of insufflated amphetamines, not oral. Here's a vice article with additional info from the doctor who conducted the study

[–] circuscritic@lemmy.ca 24 points 8 months ago* (last edited 8 months ago) (1 children)

This is objectively false.

Setting aside the issue of QA and how and in what conditions this methamphetamine is being produced, no, the pharmacological effects of methamphetamine are NOT just the same as Adderall (blend of 4 different amphetamine salts).

It's also not prescribed for ADHD, except in rare circumstances. It's mostly prescribed for conditions like narcolepsy, because it's significantly more psychoactive then amphetamine salts, and that's BEFORE you factor in issue of these being cartel produced counterfeit pressed meth pills vs production in an actual pharmaceutical laboratory with the accompanying conditions and controls.

[–] BarrelAgedBoredom@lemm.ee -1 points 8 months ago (1 children)

Im not telling people to buy crank from some dude down the street instead of going to the pharmacy for their Adderall. You're just putting words in my mouth and getting mad at them.

However, I was misremembering a study I read a few years ago. Outside of in vitro and rat studies, I couldn't find anything measuring the pharmacological effects of Adderall and meth. I should've said behavioural and physiological instead. It was intranasal instead of oral as well, for what that's worth. The behavioral effects are essentially identical and there are very minor differences in effects on heart rate and blood pressure. I will be correcting my comment after I reply to you.

[–] circuscritic@lemmy.ca 6 points 8 months ago (1 children)

I put no words in your mouth. I took your response, briefly explained why it was wrong, and then further expanded on why it was dangerous.

Your words:

Not to mention the pharmacological effects of methamphetamine are indistinguishable from Adderall when taken orally in similar doses

[–] BarrelAgedBoredom@lemm.ee 7 points 8 months ago (1 children)

And what part of that mentioned anything about sourcing meth from the streets? As far as my intentions are concerned, I was speaking strictly pure, prescribed methamphetamine, taken as prescribed. That could've been inferred from context since the comment I was replying to was about how methamphetamine is sometimes prescribed for ADHD. The conversation wasn't about street drugs and until you commented, no one brought it up

[–] circuscritic@lemmy.ca 3 points 8 months ago* (last edited 8 months ago) (1 children)

No worries, I didn't realize that you hadn't actually read the article before making your comments.

So, you can disregard my comments where I had incorrectly assumed we both actually read the linked LA Times story.

My other comments about how it's factually incorrect to say methamphetamine and Adderall are the same, those are still in bounds. Right?

Just FYI counterfeit pills sold in Mexico are either made by the cartels, or they're fake placebo bullshit (both types are mentioned in said article).

[–] BarrelAgedBoredom@lemm.ee 0 points 8 months ago

Forgot what the thread was originally about lol, my bad. I skimmed the article, I'm working and haven't given it a proper read yet. I see why you were saying all that now, that's on me and I apologize.

To say they're the same is incorrect as they are different compounds. But if we're judging them on their effects on the mind and body, taken the same way and in the same doses; they illicit a nearly identical response. If you accidentally took a meth pill instead of Adderall, it's likely you would only notice minor differences if you noticed anything

[–] banneryear1868@lemmy.world 10 points 8 months ago* (last edited 8 months ago)

I can vouch for this as someone who's tried equivalent doses of each, less methamphetamine is required to achieve the same effects but I couldn't tell the difference. Compared with the recreational forms you're also dealing with different salts combined in the prescription. This sentiment is also common.

[–] Corkyskog@sh.itjust.works 4 points 8 months ago (1 children)

I think you mean equivalent dose? Isn't meth like nearly 50% stronger?

[–] BarrelAgedBoredom@lemm.ee 6 points 8 months ago

Turns out I was misremembering a study I read a few years back. It was intranasal, not oral. They're still incredibly similar in their effects at the same dose. Here's the study. And a vice article about the study with commentary from the doctor who conducted it.

[–] Shard@lemmy.world 1 points 8 months ago

Upvote for coming back to correct a mistake

[–] CalamityBalls@kbin.social 3 points 8 months ago (3 children)

A range of amphetamine compounds are approved for the treatment of ADHD.
Methamphetamine, what people generally talk about when they say meth, is not.

[–] superduperenigma@lemmy.world 31 points 8 months ago* (last edited 8 months ago) (1 children)

Desoxyn is an FDA approved brand-name methamphetamine that is prescribed to treat ADHD and obesity. It's not very common, and usually ADHD patients will be prescribed some other amphetamine, but meth is schedule II and it is used to treat ADHD in some cases.

https://www.dea.gov/sites/default/files/2020-06/Methamphetamine-2020_0.pdf

[–] banneryear1868@lemmy.world 9 points 8 months ago* (last edited 8 months ago) (1 children)

Multiple commenters say Desoxyn isn't '"common" but at the pharmacy I worked at for 5 years we always stocked it, and had enough scripts coming in that we'd need to make sure we had inventory. This was for adhd mostly. Methamphetamine is more potent per molecule so it's not necessarily analogous with amphetamine for side effects.

[–] superduperenigma@lemmy.world 1 points 8 months ago

Interesting. To be honest, I was basing that primarily on my own anecdotal experiences. Everyone I know whose gotten a prescription for one for some other amphetamine.

[–] ale@lemmy.world 11 points 8 months ago

From another comment in this thread, at least in the US, it looks like it actually is approved for treatment of ADHD. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/005378s028lbl.pdf

[–] circuscritic@lemmy.ca 4 points 8 months ago

It is, but it's very rare. It's mostly used for issues like narcolepsy, as it's significantly more stimulating then amphetamine salts.

[–] poszod@lemmy.world 59 points 8 months ago (1 children)

Oh no that's terrible. Which pharmacies are doing that so I know the ones to avoid?

[–] cheese_greater@lemmy.world 31 points 8 months ago* (last edited 8 months ago) (1 children)

Sounds disgusting, but Which ONES, which ONES?

[–] MyNameIsIgglePiggle@sh.itjust.works 17 points 8 months ago (2 children)

I call BS unless I get a source

[–] cheese_greater@lemmy.world 4 points 8 months ago

Clever girl

[–] Got_Bent@lemmy.world 27 points 8 months ago* (last edited 8 months ago)

Do these pharmacies by chance serve fried chicken or offer commercial laundry services?

[–] ale@lemmy.world 15 points 8 months ago (1 children)

Isn't Adderall basically meth? Is there a difference in how they would affect ADHD symptoms at low dose?

[–] cheese_greater@lemmy.world 23 points 8 months ago* (last edited 8 months ago) (1 children)

Its similar but the additional methyl group makes it more potent.

Kinda like a morphine (Adderall) vs heroin (meth)

[–] GiveMemes@jlai.lu 29 points 8 months ago* (last edited 8 months ago) (3 children)

This is not true. The extra methyl group makes it cross the blood brain barrier faster. The extra potency is from the drug itself being different from dexampphetamine, the active ingredient in adderall, however it is important to note that at doses below 50 mg methamphetamine and 100mg adderall, effects are almost entirely the same, with the serotoninergic (is this a word ?) aspects of meth only coming from high doses.

Do not recommend either.

[–] cheese_greater@lemmy.world 15 points 8 months ago* (last edited 8 months ago)

If something hits harder and faster, I'm pretty sure definitionally its more potent.

Potency is a function of its effect relative to the amount used. Like this is more of "yes, AND" type deal, I'm not wrong and you're right to elaborate that this is due to its increased abillity to permeate BBB

different from dextroamphetamine

Unless we're getting into racemics , I'm saying its basically amphetamine + methyl group, lets not get so granular here

Also, meth and amphetamine can be taken such that the doses are equipotent, it would just be less meth and more amphetamine by weight/dosage (all other things like ROA and context being equal)

Re:Serotonin: I believe amphet and meth both affect serotonin dose dependant but I dont think there's any way to say only meth also implicates serotonergic release or transmission

[–] DrBob@lemmy.ca 7 points 8 months ago

Thank you! I'm normally the crank making this comment. Also don't forget for the heroin example that the acetyl groups get cleaved after crossing the BBB so it goes back to being regular ol' morphine before it can bind to a receptor.

[–] banneryear1868@lemmy.world 1 points 8 months ago

Serotonergic which is minor in high amphetamine doses, they're more dopaminergic. Serotonin is more SSRIs and psychedelics.

[–] fne8w2ah@lemmy.world 9 points 8 months ago

Did they mean methylphenidate?

[–] irdc@derp.foo 8 points 8 months ago

That sounds like uncontrolled dosages of Desoxyn.

[–] SendMePhotos@lemmy.world 2 points 8 months ago
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