Casey's video is interesting, but his example is framed as moving from 35 cycles/object to 24 cycles/object being a 1.5x speedup.
Another way to look at this is, it's a 12-cycle speedup per object.
If you're writing a shader or a physics sim this is a massive difference.
If you're building typical business software, it isn't; that 10,000-line monster method does crop up, and it's a maintenance disaster.
I think extracting "clean code principles lead to a 50% cost increase" is a message that needs taking with a degree of context.