this post was submitted on 21 Jul 2025
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I just started Zepbound, a GLP-1 agonist similar to Ozempic (CW eating disorders) (hexbear.net)
submitted 3 weeks ago* (last edited 3 weeks ago) by VibeCoder@hexbear.net to c/chat@hexbear.net
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Context:

  1. I am almost 400 lbs
  2. I’m also being tested for sleep apnea
  3. I am diagnosed with binge eating disorder, which I’ve been taking Vyvanse for as well as for my ADHD
  4. I’m on the lowest dose of Zepbound, which will titrate up over time
  5. I’ve been on it a few days
  6. I gained quite a bit of weight after starting a microdose of estrogen, so there’s aspects of that in play as well
  7. I somehow managed to get my insurance to cover it with a copay of $15 for 4 weeks of meds (I went in expecting the price to be a prohibitive barrier and ready to be let down so this was a great surprise)

It’s kind of hard to describe how night-and-day it is. I had to google how quickly the effects happen because I thought I was gaslighting myself. Within hours of my first injection, I went from being unable to feel hunger until I was starving and being unable to feel full until my stomach hurt to being able to stop eating whenever I wanted. I can eat a normal amount of food and feel full. No nausea. No metal taste. None of the side effects that people complain about so far. I still enjoy the food. But for the first time in years I can stop thinking about food and having it invade my sense of free will.

All I can say is that if this is a normal relationship to food, everyone who’s ever implied I just wasn’t trying hard enough can go fuck themselves.

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[–] SootySootySoot@hexbear.net 2 points 3 weeks ago* (last edited 3 weeks ago)

I'm late to reply, but YES. There is still emerging, vague data that artificial sweeteners may actually fuck up your body's response to sugar in very poorly understood ways.

The idea being that when you taste sweetness, your body starts doing stuff to prepare for sugar - secreting gastric acid, making insulin, etc. but when the sugar doesn't actually arrive, it gets confused and starts adapt - instead learning to NOT react properly to sugar, so that it fucks you up even worse than just having excess sugar. The small initial studies suggest (possibly very significantly) exacerbating diabetes, obesity, fatigue, acid reflux, while preventing you getting what your body needs from sugars.

Still very preliminary and hard-to-pin-down research, but the plausible mechanism could result in (possibly unrevertable?) inability to healthily digest your food.