The "easiest" would be Israel since my wife qualifies under the Law of Return, but we're both staunchly anti-Zionist, so... ugh. Right now I'm looking closest at Ireland, since my profession is on the Critical Skills Employment Permit list and I work in a niche that is well-matched to the Irish pharma/life sciences sector. In a pinch I'd lobby for a transfer to my company's Canadian branch office, but that's not optimal for a few reasons.

ETA: for permanent emigration, the thing you want to do is find a country where you can speak or at least quickly learn the language, and where you can get employment in a sector that's on their list of critical needs. In most cases you can't get a visa that lets you stay and work long-term without first getting a job offer. In terms of flexibility, someplace in the EU has a lot of appeal, since you can work basically anywhere in the Schengen area after you gain permanent residency. Australia and New Zealand are attractive mainly for being well-isolated from all the regional wars that seem like they're waiting to kick off just as soon as American muscle isn't backing up NATO or Taiwan, but it's a lot harder to get those visas.

Come to California. We'll fight.

...but seriously, I've been learning French for almost four years now (a) in order to widen my options beyond the Anglosphere in general, and (b) because a whole bunch of tropical islands are part of France (including Tahiti) and I'd like to get a liveaboard sailboat and visit some of them.

I figure having a specific destination planned becomes less important if you're taking your home with you. It's really being able to get out before the shit hits the fan that's the issue, and not having to worry about finding a job willing to sponsor a work visa in order to settle in a particular place seems like it would make that easier.

Worst-case scenario, if the boat's cheap enough your living expenses can be low enough to support yourself bouncing around from port to port working odd jobs.