Fallout: Tactics is set in the Midwest. A BoS expedition is sent to explore the Midwest. Things go to shit and they end up stuck there with limited resources, so they start recruiting the local riff-raff in to the BoS. One thing leads to another and they end up fighting an escalating series of increasing weird factions. It turns out all the chaos is being driven by a serious threat that could overrun the whole midwasteland. The BoS troops recruit a ragtag armor of super mutants, deathclaws, ghouls, tribals, psychics, and robots to fight their way to the core of the problem and save the wasteland.
It's a fun game, very solid squad based tactics using the SPECIAL system, inventive enemies, lots of fallout weirdness.