2 very different genres, since you didn't specify:
FlatOut 2 is a fun, fast-paced arcade racing game that can be played with one hand. You just need the cursor keys and Ctrl for Nitro.
In Papers Please, you work at a Soviet-like country's border crossing and have to check every immigrant's details while making difficult moral decisions under time pressure. Mouse only.
this post was submitted on 11 Apr 2025
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A large proportion of games that have both mobile and PC releases are going to be designed around mouse-only use.
You could try of The Devil! It's an episodic indie cyberpunk courtroom mystery game and the first episode is free. (also i've been obsessed with it lately and need more people to talk about it pls pls pls)
Settlers.
Shogun showdown
Microsoft Solitaire Collection
airborn empire is a fun city builder/resource management game
Btw: There are USB foot keyboards on the soulless online marketing platform of your choice. They can usually be programmed to different keys or combinations. While it is not something I would use for FPS gaming, it can come handy in situations like yours. I have one with three different switches that are programmable which is quite handy.
Nubbys Number Factory, addicting and mouse only.
X-COM 2 is fully playable with just the mouse.
If you're looking for something a bit lighter, there's The Enchanted Cave 2, a nice little roguelite with an interesting loot system.
From memory, Fallout and Fallout 2 are fully mouse-playable too.
If you rebind the pause/unpause button, Starsector can be played mouse only too.
Scarlet Hollow
Lonestar if you like or are interested in roguelike deck builders. There are a lot of great games coming out in that genre, here are some others I like:
Balatro
Slay the spire
Bounty of One (not a deck builder, just a roguelike)
Edit: I just realized some of these were already suggested but I'll leave it
I installed PPSSPP on my phone and paired a switch joycon. Played through a few really good games that way when my kid required being held to sleep. I'd imagine you could pair one to your computer and find some games that you'd like.
Citizen Sleeper and Citizen Sleeper 2 can both be played entirely with just a mouse. No keyboard inputs needed.