I am running a full node with the Official Monero GUI and also mining. I have not broken that connection in several days since I own a computer that doesn't need a reboot several times a day, so I haven't noticed any problems yet. Will update thread if I notice anything after power restart.
As a point of reference, when I first sync a full node after installing GUI or CLI program, it's not unusual at all for the first sync to take three or four days. I've done it several times.
Interested in Nostr, but it appears Gossip client for Linux is not ready for prime time. I will not allow clipboard paste of Npub with Ctrl-V. Looks like I may have to wait for another version when these bugs are worked out.