North Sentinel Island is an island de-jure owned by India but is de-facto self-governing. It is illegal to visit the island due to how dangerous it is, along with the risk of spreading diseases that the inhabitants do not have any resistance to.
The island is inhabitated by around 50-500 (true number unknown) indigenous people who have inhabited the island for over 60,000 years. The Sentinelese people are well-known to attack most outsiders who dare to come visit the island. Apparently, one major catalyst was when a British man kidnapped an elderly couple and four children. The couple died and the children were returned but had serious diseases which may have spread to the rest of the islanders.
In 2018, an American tourist illegally visited the island in order to attempt to convert them to Christianity. He was later killed by the Sentinelese.
I don't why, but for some reason, this island is quite fascinating. There is so little known about it. The very concept of an isolated society that wants to be left alone is something that I find interesting.
Have any two cents to give?
I imagine that if there was a serious existential threat to the region and/or all life on Earth, it would be wrong to not contact them, such as a mega-tsunami of the century, an asteroid impact, a potential quasar blast, the eventual warming of the Sun, or of humanity needing to leave the Earth in space arks.