this post was submitted on 13 May 2024
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shitty effortpost incoming (hopefully it's readable, NO i will not capitalize top-use-words :

this is something i've been kicking around in my head after hearing rumors about kratom or other mu-agonists and their effects on hormones from the usual reddit broscientists. i did a little digging in an effort to explain some shit in my past and maybe others have had similar experiences and want to understand their former or current addictions:

i have found a one paper proposing chronic opioid use can lower testosterone levels. this is something i had heard rumors of before 2020 and it answers some nagging questions i've had

when i was much younger i had a short, intense addiction with heroin and other potent opioids. unlike my other junkie friends i was a unique case. i didn't like to nod and didn't seem to get the same buzz they did. instead i was uplifted, energized, and over time starting chasing what i now know as gender euphoria instead of the actual drug effects. i had a vague connection that "opioids = girl" but thought it was all in my head just as i thought being trans was back then

this might also explain why i have some lasting features of someone that did a partial hormonal transition. tender sensitive breasts/nipples, some "man boobs" that don't make sense based on my fat distribution, permanent soft baby face that lesbians seem to love, some body fat distribution that doesn't fit my otherwise hyper-masc body, and the way my junk functions now

after i was locked up i was basically at one of my most intense phases of addiction and this was before i got out and went hard on strength training. at the time i was still big but very enby presenting, smooth, and i easily hairline fractured my spine while locked up (possibly another effect of uncontrolled hormone fuckery?)

i still take kratom regularly as a way to avoid even thinking about seeking real opioids, but i wonder if it's just my way of keeping a lid on my T levels too. i don't get high from it but it does keep me feeling sane. i'll have more anecdotal data once i finally get on a proper E regimen and see if my kratom dose can be easily tapered.

i think it will. now please, DO NOT use this as an excuse to go seek out opioids for gender dysphoria. i do think this may explain why opioid abuse is so prevalent among transfemmes (besides the usual reasons) but we are a long way from making scientific connections there. it's an uncontrolled messy way to suppress T levels and will fuck your life up, especially with whats in today's junk. i was "lucky" enough to only have access to the finest smuggled afghani heroin smuggled over by our men in uniform and Langley and it still killed most of my friends.

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[โ€“] AutomatedPossum@hexbear.net 13 points 1 year ago (1 children)

I never fucked with H, but i had extremely similar experiences when i dabbled in opioids during the drug nerd phase i went through as an egg. I didn't use anything regularly, so i can't weigh in on effects of prolonged T suppression (and tbh the testosterone blood levels in the paper sound like nothing to write home about when you compare them to standard dosages of actual anti-androgens, i'm at about a tenth of that with 5mg cypro/d), but the whole "gender euphoria instead of sedation" thing is something i always felt to a really extreme degree when i got high. These were genuinely the only times i ever felt at home in my body before my egg cracked and i got on E, and it made me go completely nuts, the joy of feeling whole was indescribable. I didn't make the connection what "tilidine makes me feel like Major Kusanagi in a new cybernetic body" said about my relation to my gender, and i couldn't know back then that all the weird psychosomatic pain i was in (and that disappeared on opioids) was my way of expressing dysphoria before i properly understood it. But in hindsight, it's kinda obvious what was going on there.

[โ€“] Des@hexbear.net 5 points 1 year ago

opioids, as a drug, just have incredible "feminine energy" to be non-scientific about it, don't they? i mean historically i think they always have been placed in that category. much of it just based on racism (chinese with opium) but there might be something real there at the neurochemical level.

i know some of the deeper far downstream of simple receptor agonism/modulation/antagonism are still a scientific frontier. we know how to trip the receptors but the cascading effects to other neurological systems are still often mysterious because it's hard to test in vitro and nearly impossible to do clinical trials. so maybe opioids in their action with the mu receptor causes a direct but fleeting downstream effect on blood hormone levels, even if temporary and maybe not for everyone

maybe we both got a blast of endro estrogen as a side dish by nature of our transness every time we used a mu-agonist. it could be as rare as trans people are, making it difficult to study (i mean how many trans opioid addicts would volunteer for a clinical study that can't even be legally performed in the U.S.)

it would be crazy if thirty years from now we reverse engineer what gender euphoria actually is and find out it's tied to the bodies natural beta endorphin system and there is a direct connection between the two

[โ€“] Cromalin@hexbear.net 7 points 1 year ago (1 children)

i remember looking this up after seeing it in relation to the kurt cobain post, it seems fascinating though obviously extremely difficult to find any actual concrete data for

[โ€“] Des@hexbear.net 4 points 1 year ago (1 children)

i missed this post thank you for linking to it!

as an elder millennial, i nirvana was already legendary and cobain dead by the time i got into music in my late teens. (not going to assume Cobains pronouns so will use accepted ones) but i saw his videos and listened to some of his music and always saw something at least a bit genderqueer about him

the 90s sucked for being trans because it was too early for strong internet communites and all media about it sucked. just little islands of doubt and lonliness unless you were already embedded in urban queer communities. makes me wonder if he got a few E shots into himself instead of H would things have gone different

[โ€“] Cromalin@hexbear.net 3 points 1 year ago

it's one of the best things i've ever read tbh, i think everyone should have to read it