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this post was submitted on 19 Aug 2024
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Anyone here who has experience using pioglitazone for better fat redistribution? I finally managed to source some and I’m quite excited to try it out
pioglitazone sounds like an obscure regional italian delicacy
True, hopefully it will also turn me into a delicacy
I have literally never heard of that before but tell me more. I've always hated my body fat distribution and want that to move ASAP
From my understanding, it makes it so that new weight you gain goes to your lower regions, i.e. buttocks, thighs, etc. So you have to gain weight while using it, but it can have some pretty bad side effects so make sure to read up on those before trying it. I found a decent writeup about it on reddit I can send you.
yeah that's the general vibe i got from it. which is unfortunate as right now I'm trying to lose weight rather than gain it but maybe one day
Have you read this page: https://grayoasis.com/post/3
I haven't tried Pio but I know a few people online who have. They usually get good results but it's not clear to me if it lasts after they stop or if it's safe long term.
Omg I’ve been looking for that page for some time. I read it a while ago, but couldn’t find it again.
I’ve seen some people mention that the results stayed after stopping pio. I guess it makes sense since the adipose cells go to the places that are in line with a female fat distribution so as long as you stay on HRT I’d assume it to stay.
I’ll definitely report back when after I try it. My plan is to switch back to DIY injections, and then try prog and pio for about 3 months while putting on like 10-20 lbs, but first I need to spoof my blood test so the gender clinic doesn’t know what I’m doing😅
Oh and I definitely dont’t think it’s safe long term. Some of the side effects are bladder cancer, bone density issues and heart failure.
Pio seems to interact with mesenchymal stem cells and a study (though not done on humans) showed transdifferentation of bone marrow mesenchymal stem cells into adipose cells IIRC. Mesenchymal stem cells also act as the prescursor to many other cells such as muscle and cartilage cells, so it’s probably not too good to affect those too much😅