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submitted 6 months ago by m3t00@lemmy.world to c/science@lemmy.world

In trials

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[-] MajesticSloth@lemmy.world 167 points 6 months ago

When this was posted before someone who followed it fairly closely and others like it, updated the thread with info because the article was behind current info. They had already stopped the trials for MS because it wasn't working. So they began to just focus on one other, the Crohn's, I believe. Figuring if they got one to work, they could go back to the others and get them on the right track.

I have MS, and while this is a new approach, there have been so many articles about treatments that end up going nowhere after the first excitement. So it is still very early to get hopes up.

Hope can be a dangerous thing. Hope can drive a man insane, as Red said.

[-] kromem@lemmy.world 56 points 6 months ago

Is it possible that other person was just full of shit?

Here was an update posted on Sept 12th, 2023 from the company behind the trials regarding the MS trials:

Anokion has completed patient enrollment early in the second and final MAD cohort of its MoveS-it (Multiple Sclerosis Study of ANK-700 to Assess Safety and Immune Tolerance) clinical trial to evaluate ANK-700 for the treatment of patients with multiple sclerosis. MoveS-it is a randomized, double-blind, placebo-controlled Phase 1 study evaluating ANK-700 for the treatment of patients with relapsing remitting multiple sclerosis (RRMS). MS is a demyelinating disease of the CNS, in which the immune system attacks the myelin sheath in the brain and spinal cord. RRMS is the most common type of MS, characterized by recurring episodes of new or worsening symptoms. Anokion has designed ANK-700 to re-educate the immune system by inducing antigen-specific tolerance to myelin-based autoantigens to reduce neuroinflammation in the brain and spinal cord.

Safety data from both the SAD and MAD cohorts supports that ANK-700 is safe and well-tolerated at all dose levels tested through the dose escalation period. Further, preliminary biomarker data from the MAD cohorts displays trends in antigen-specific immune tolerance and evidence of bystander suppression to related myelin antigens, which is critical to treating complex autoimmune diseases like MS.

The study will continue with a 12-month safety follow-up expected to complete in the first half of 2024. Anokion anticipates reporting full results from its MoveS-it clinical trial in the second half of 2024.

This says that the single dose (SAD) phase 1 trial which began in 2020 was completed and they moved on to the second multiple ascending dose trial (MAD) for MS which completed enrollment and expect results in 2024. And that the preliminary data from the first MAD trial indicates therapeutic response.

And the press release talks about how they've moved on to a phase 2 trial for its use for celiacs (the initial trial use case). And then on Oct 12th they announced they will be presenting data from their phase 1 for celiacs at a conference.

A week after the announcement quoted above they released the news about their peer reviewed paper mentioning the early success in both (what likely inspired OP's article), saying:

We have now observed our approach play out in the clinic with early data from our lead programs in celiac disease and multiple sclerosis, KAN-101 and ANK-700, that demonstrated antigen-specific tolerance, bystander suppression, and an impact on disease-specific biomarkers.

None of this looks like a company that has a failing drug on their hands. And there's no indication of the MS trial being ended early - the only thing that happened early was completing enrollment early.

Being too ready to give up on hope is its own kind of insanity.

[-] evatronic@lemm.ee 34 points 6 months ago

T1 diabetes here. A cure is just 5 years away...

They told me, when I was diagnosed in 1992.

[-] Lmaydev@programming.dev 18 points 6 months ago

It always 5 years if properly funded. It's never properly funded so always 5 years.

They are testing an artificial pancreas currently. The cost is the issue as always.

[-] AnyOldName3@lemmy.world 9 points 6 months ago* (last edited 6 months ago)

We can genetically engineer bacteria to mimic the missing pancreatic cells, and it's not too different to the way most insulin is produced as all that's new is the system to stop producing insulin when blood sugars are already low enough. However, if you put them in a person, the immune system attacks the bacteria, so they need isolating. To do that, we need a membrane that lets sugar in and insulin out, but doesn't let antigens or live bacteria out, and doesn't let immune cells in. Even if the bacteria are held in place, if immune cells can get in, it's no better than a pancreatic transplant as you'll still need immunosuppressants, and they're generally worse than dealing with type one manually. Development of the membrane keeps hitting unexpected hurdles, so artifical pancreases are still unable to start trials, and then they might take a decade.

There are other approaches, e.g. using electronics to control photosensitive insulin producing bacteria, but they don't have any advantages (the membrane still has to let sugar in so the bacteria can eat) and have more things that can go wrong.

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[-] nul9o9@lemmy.world 14 points 6 months ago

Well damn, I got MS too but caught it fairly early. I'm hoping for a major breakthrough before it gets really bad.

[-] Lycerius@lemmy.world 7 points 6 months ago

I came for the Orange reference, but was not disappointed by Red.

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[-] FrankTheHealer@lemmy.world 50 points 6 months ago

Website I've never heard of: check

Wild claims that seem too good to be true: check

Little to no proof about said claims: check

Don't get me wrong, this would be fantastic if it's true. But I'm sceptical. It feels like all those articles about a cure for cancer that then never go anywhere.

[-] kerrigan778@lemmy.world 8 points 6 months ago

Here's the article that should have been posted, except of course that it's a few months old and nothing new has been reported on it yet that I know of. https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases

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[-] Son_of_dad@lemmy.world 37 points 6 months ago

Every science article is just a comment section disapproving the article. That's why I stay away from these science communities, it's all clickbait and lies

[-] c0mbatbag3l@lemmy.world 15 points 6 months ago

At the same time, commenters don't necessarily know what the fuck they're talking about either.

[-] Meowoem@sh.itjust.works 6 points 6 months ago

Yeah Reddit always had that problem, I think it's here too - top rated comment is someone saying it won't work and the article is wrong, everyone just accepts it without question.

I still see people using battery breakthrough stories as an example of stuff that never comes too market despite most of them being in the very phone the person is using.

I genuinely think a lot of them are just people who hate science and engineering so don't want people to be interested in it

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[-] phoenixz@lemmy.ca 9 points 6 months ago

Looks at that.... The one thing good about reddit was the /r/science sub, it was always full of moderator deleted comments that were off topic, factually incorrect, etc. posted articles actually were scientific reports and not clickbait crap lik this

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[-] avidamoeba@lemmy.ca 32 points 6 months ago

This sounds quite exciting and it doesn't smell like bullshit.

[-] Tylerdurdon@lemmy.world 14 points 6 months ago

Probably extremely affordable at 3 million a pop for 5 shots.

[-] partial_accumen@lemmy.world 21 points 6 months ago* (last edited 6 months ago)

Easy hack. Get a bunch of more affordable health care services during the year until you reach your out-of-pocket max, then go in and get your 3 million worth of shots all on the insurance company's dime with zero extra cost to you.

[-] plz1@lemmy.world 28 points 6 months ago

Your claim was denied, due to the insurance provider classifying this treatment as elective or cosmetic, not life saving.

[-] dylanmorgan@slrpnk.net 16 points 6 months ago

Ah, I see you’ve interacted with the American “health insurance” extortion racket.

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[-] Mouselemming@sh.itjust.works 5 points 6 months ago

Or do this one first to max out your out-of-pocket with the one copay, everything else is "free" all year.

"" because you're still paying premiums

[-] gibmiser@lemmy.world 7 points 6 months ago

Article from September. First I'm hearing of it...

If we assume for a moment that it works as advertised - what is it that makes this a vaccine? To me it sounds like a cure or treatment.

[-] Kethal@lemmy.world 54 points 6 months ago* (last edited 6 months ago)

The creators call it an inverse vaccine. A vaccine causes the immune system to recognize a compound to attack. This treatment causes the immune system to ignore a compound it had previously recognized. So they are specifically saying it's not a vaccine (and OP is misrepresenting them), even though that word is in the phrase, something roughly like antivenom is not a venom.

Thanks for the additional clarification!

[-] winterayars@sh.itjust.works 12 points 6 months ago

It is not a cure for the reasons others in this thread have stated. It doesn't repair damage already done, it only prevents the disease from advancing. That's still a huge deal, though.

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[-] luna@lemmy.catgirl.biz 24 points 6 months ago

Oh fuck yes! I hope this works so badly (living the nightmare with crohns)

[-] Dhs92@programming.dev 8 points 6 months ago

I wonder if it also applies to ulcerative colitis...

[-] CleoTheWizard@lemmy.world 7 points 6 months ago

Same here friend. The disease is rough and hits everyone differently. Hope you’re doing alright with things tho :)

[-] Bo7a@lemmy.ca 9 points 6 months ago

I would give anything to be rid of this disease. I haven't slept a full night since 1996. And the pain... And it always seems like nobody understands. 'Oh him? He just poops a lot, ignore the doom and gloom.'

[-] NMBA@mstdn.ca 5 points 6 months ago
[-] toiletobserver@lemmy.world 24 points 6 months ago

Only "ten more years to cure diabetes"

-Science 30 years ago

[-] BloodSlut@lemmy.world 6 points 6 months ago

This still wont cure diabetes, but it will prevent it from developing or advancing if you catch it early enough.

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[-] Downcount@lemmy.world 22 points 6 months ago

In my understanding this could reverse the autoimmune reaction to Type 1 Diabetes not regrow the already killed β-cells.

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[-] ICastFist@programming.dev 19 points 6 months ago

Call me when the human trials give a positive return

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[-] chaosppe@lemmy.world 13 points 6 months ago

Awesome, I have an autoimmune desease that can possibly paralyse me in future. I hope progress can continue 🙏

[-] Xtallll@lemmy.blahaj.zone 12 points 6 months ago

I wonder if a similar technique could be used to reduce organ transplant rejection.

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[-] Nacktmull@lemm.ee 10 points 6 months ago* (last edited 6 months ago)

What about Hashimoto's thyroiditis and Graves' disease?

[-] Jackcooper@lemmy.world 10 points 6 months ago

That's a bold claim there, dennis

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[-] Chainweasel@lemmy.world 8 points 6 months ago

Sounds pretty advanced. I bet they won't be able to activate the mind control chips until 6G cell services launch.

[-] krotti@sh.itjust.works 5 points 6 months ago

I was under the impression that we were 5G access points with the covid vaccine?

Was I lied to? I thought I was doing a service to the fellow terminally online.

[-] MisterChief@lemmy.world 7 points 6 months ago

I remember seeing something on reddit about this earlier this year iirc. Definitely exciting and I certainly hope there is credence to this. Would love to see auto immune disorders go by the wayside in the next couple decades. Once they fix all the real bad ones I hope they make one for vitiligo, I'm tired of 70 spf sunblock and weird looking tans.

[-] Bransons404@lemmy.world 6 points 6 months ago

Is this the "T1D cure in 10 years" I was promised 21 years ago?

[-] dunz@feddit.nu 5 points 6 months ago

This looks promising, way more promising than any other cure for MS I've read about

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this post was submitted on 20 Dec 2023
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